Slack / Private Message Drop — page 313

[thread - ID: 2020-12-14 09:56:19] @Robert Garry Yeah both of those... [2020-12-14 10:20:16] [Kristian Andersen] https://nextstrain.org/ncov/global?c=gt-S_681 [2020-12-14 10:29:53] [Robert Garry] "Or do we know of any asymptomatic shedders - which would allow for the transmission if the person was out and about?" This is the question we're going to answer one way or the other if the vaccines are not that good at sterilizing immunity (hopefully most are). [2020-12-14 10:43:10] [Kristian Andersen] My money is on sterilizing immunity - without that, oh boy... [2020-12-14 10:47:05] [Robert Garry] Oh boy is right - this is why I really really wanted to do human challenge studies. [2020-12-14 10:48:14] [Kristian Andersen] Yeah... [2020-12-14 11:51:29] [Eddie Holmes] This does look like the sort of evolution I saw in cases of virus evolution in immunocompromised hosts. I've never quite understood why you see so much evolution in antigenic proteins in patients should not be mounting an immune response. Very striking in the noros. [2020-12-14 12:31:44] [Andrew Rambaut] Yes - noros is a good example. You have very long term shedders with basically no symptoms. [2020-12-14 12:32:53] [Andrew Rambaut] Perhaps it is the weakened immune response rather than an absent one which enhances selection by providing the chance for mutants to arise. [2020-12-14 12:53:29] [Kristian Andersen] Yup, I think "weak, not absent" may be key here. [2020-12-14 13:20:50] [Eddie Holmes] Agreed. [2020-12-14 14:43:29] [Robert Garry] Here's your FOI friends Eddie - they apparently got about a TB of Baric's emails. https://usrtk.org/biohazards-blog/new-emails-show-scientists-deliberations-on-how-to-discuss-sars-cov-2-origins/ [2020-12-14 14:46:36] [Andrew Rambaut]