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Slack / Private Message Drop, p.1030 [SLACK_001244] · slack_pm:msg:10768

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Would be happy to work with you all on this.

In context

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2021-11-26 09:04 Andrew Rambaut open

OK. Peeps. We are definitely considering the human->animal->human origins of Nu (as it may or may not be called).
2021-11-26 09:04 Andrew Rambaut

Would be happy to work with you all on this.
2021-11-26 09:06 Andrew Rambaut open

We are currently looking for the closest potentially basal genome in humans but at the moment it definitely looks like being 2020. I am struggling to see how a that could be a chronic infection followed by transmission. I doubt an HIV patient would survive that long with a CoV infection doing all this shit.
2021-11-26 09:07 Andrew Rambaut open

A non-human host would also explain adaptation in the RBD to a different ACE-2? It may have antigenic consequences in humans but that is coincidental because it is the RBD
2021-11-26 09:07 Robert F. Garry open

CHeck out the figure in the other channel - 7-of 7 mutations seen in rodents are in Nu - that's unlikely....
2021-11-26 09:08 Andrew Rambaut open

We are working with Tulio on this so I would prefer not to broaden it out too much.