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Slack / Private Message Drop, p.1027 [SLACK_001241] · slack_pm:msg:10731

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This is mind blowing - BANAL-52 is closer to Hu-1 in the spike (in AA space) than the Botswana sequences are.... Holy fuck.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-11-24 08:53 Robert F. Garry open

Good - that would just encourage the Leakers...
2021-11-24 08:54 Kristian G. Andersen open

Yeah, very clearly not a conscious choice - just nature doing it's thing. All it took was a virus with a landing site and then stuff comes and goes around that site all the time - just had to be the right sequence that popped in.
2021-11-24 08:55 Robert F. Garry open

Yup - nature - we get to see the brilliance but only afterwards.
2021-11-24 09:02 Kristian G. Andersen open

Some alignments with these sequences combined with relevant SARSr-CoVs - just FYI. [shared file(s): 2021.11.24_alignment_spike_nt.geneious, 2021.11.24_alignment_spike_aa.geneious, 2021.11.24_alignment_spike_aa_minimal_annotated.geneious]
2021-11-24 09:03 Kristian G. Andersen

This is mind blowing - BANAL-52 is closer to Hu-1 in the spike (in AA space) than the Botswana sequences are.... Holy fuck.
2021-11-24 09:04 Kristian G. Andersen open

98.4% vs 96.9%
2021-11-24 09:10 Robert F. Garry open

Yeah - what I really want to do is put the PRRA into BANAL-52 and see how it does several species.
2021-11-24 09:11 Kristian G. Andersen open

What the heck is up here - Hu1 on top, Botswana at the bottom [shared file(s): Screen Shot 2021-11-24 at 9.07.10AM.png]
2021-11-24 09:12 Kristian G. Andersen open

In AA space: [shared file(s): Screen Shot 2021-11-24 at 9.07.32 AM.png]