COVID-19 Records

Chat message

Slack / Private Message Drop, p.1027 [SLACK_001241] · slack_pm:msg:10734

Page text: p.1027 · original PDF

Date
2021-11-24 09:11
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

What the heck is up here - Hu1 on top, Botswana at the bottom [shared file(s): Screen Shot 2021-11-24 at 9.07.10AM.png]

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

  1. 2021-11-24 09:02 Kristian G. Andersen open
    Some alignments with these sequences combined with relevant SARSr-CoVs - just FYI. [shared file(s): 2021.11.24_alignment_spike_nt.geneious, 2021.11.24_alignment_spike_aa.geneious, 2021.11.24_alignment_spike_aa_minimal_annotated.geneious]
  2. 2021-11-24 09:03 Kristian G. Andersen open
    This is mind blowing - BANAL-52 is closer to Hu-1 in the spike (in AA space) than the Botswana sequences are.... Holy fuck.
  3. 2021-11-24 09:04 Kristian G. Andersen open
    98.4% vs 96.9%
  4. 2021-11-24 09:10 Robert F. Garry open
    Yeah - what I really want to do is put the PRRA into BANAL-52 and see how it does several species.
  5. 2021-11-24 09:11 Kristian G. Andersen
    What the heck is up here - Hu1 on top, Botswana at the bottom [shared file(s): Screen Shot 2021-11-24 at 9.07.10AM.png]
  6. 2021-11-24 09:12 Kristian G. Andersen open
    In AA space: [shared file(s): Screen Shot 2021-11-24 at 9.07.32 AM.png]
  7. 2021-11-24 09:13 Kristian G. Andersen open
    Here's the key part of the RBD - contact residues listed in purple above. This makes me believe this could be evolution in a non-human host, so I'll have to change my 70/30 odds to 50/50 based on this alone. This is very interesting. [shared file(s): Screen Shot 2021-11-24 at 9.08.55 AM.png]
  8. 2021-11-24 09:24 Robert F. Garry open
    Agree - it's freaky!
  9. 2021-11-24 09:24 Kristian G. Andersen open
    The insertion ("TAGTGCGTGAGCCAGAA") around 630 could be interesting - obviously a short sequence, but it ain't from SC2 itself and the top BLAST results match fungi, cholera, and a fish...

Full conversation →