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1. 2021-11-24 08:23 Andrew Rambaut open
   It must surely be from a immunocompromised chronic infection. Possibly a dual infection with recombination and heavy mutation. But the random traveller in HK has me very worried
2. 2021-11-24 08:24 Andrew Rambaut open
   Visited South Africa for 20 days - must be a much more prevalent virus than the sequencing suggests
3. 2021-11-24 08:24 Andrew Rambaut open
   Will cause S gene dropout and I think SA is seeing some signal of that apparently
4. 2021-11-24 08:29 Kristian G. Andersen open
   HIV patient or animal reservoir - I'll say 70/30 odds.
5. 2021-11-24 08:32 Kristian G. Andersen
   Bob, presumably the N679K combined with P681H makes this a better FCS, correct? It's interesting to see E484A inthere too - presumably E484K was a bit too much.
6. 2021-11-24 08:33 Kristian G. Andersen open
   I swear to god - if we see another monster variant gain territory here in November/December, something is driving the emergence. What, I don't know, but "something".
7. 2021-11-24 08:35 Robert F. Garry open
   Yes definitely better FCS - the RXXR site really is minimal. Any changes that put postive charges, K, R, H nearbyare going to up the efficacy. It already as discussed has an effective furin landing site in QTQT
8. 2021-11-24 08:37 Robert F. Garry open
   LPAI goes from a minimal site to multiple basic residues in HPAI... [shared file(s): image.png]
9. 2021-11-24 08:37 Kristian G. Andersen open
   Yup. QTQT is a landing site?

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