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Slack / Private Message Drop, p.1025 [SLACK_001239] · slack_pm:msg:10711

Date: 2021-11-24 08:35
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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Yes definitely better FCS - the RXXR site really is minimal. Any changes that put postive charges, K, R, H nearbyare going to up the efficacy. It already as discussed has an effective furin landing site in QTQT

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-11-24 08:24 Andrew Rambaut open

Will cause S gene dropout and I think SA is seeing some signal of that apparently
2021-11-24 08:29 Kristian G. Andersen open

HIV patient or animal reservoir - I'll say 70/30 odds.
2021-11-24 08:32 Kristian G. Andersen open

Bob, presumably the N679K combined with P681H makes this a better FCS, correct? It's interesting to see E484A inthere too - presumably E484K was a bit too much.
2021-11-24 08:33 Kristian G. Andersen open

I swear to god - if we see another monster variant gain territory here in November/December, something is driving the emergence. What, I don't know, but "something".
2021-11-24 08:35 Robert F. Garry

Yes definitely better FCS - the RXXR site really is minimal. Any changes that put postive charges, K, R, H nearbyare going to up the efficacy. It already as discussed has an effective furin landing site in QTQT
2021-11-24 08:37 Robert F. Garry open

LPAI goes from a minimal site to multiple basic residues in HPAI... [shared file(s): image.png]
2021-11-24 08:37 Kristian G. Andersen open

Yup. QTQT is a landing site?
2021-11-24 08:40 Robert F. Garry open

yes both are neutral polar animo acids
2021-11-24 08:42 Andrew Rambaut open

I assume you say it cutie-cutie?

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