A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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Oh boy - it's getting more polybasic - that's not good....
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It must surely be from a immunocompromised chronic infection. Possibly a dual infection with recombination and heavy mutation. But the random traveller in HK has me very worried
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Visited South Africa for 20 days - must be a much more prevalent virus than the sequencing suggests
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Will cause S gene dropout and I think SA is seeing some signal of that apparently
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2021-11-24 08:29
Kristian G. Andersen
HIV patient or animal reservoir - I'll say 70/30 odds.
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Bob, presumably the N679K combined with P681H makes this a better FCS, correct? It's interesting to see E484A inthere too - presumably E484K was a bit too much.
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I swear to god - if we see another monster variant gain territory here in November/December, something is driving the emergence. What, I don't know, but "something".
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Yes definitely better FCS - the RXXR site really is minimal. Any changes that put postive charges, K, R, H nearbyare going to up the efficacy. It already as discussed has an effective furin landing site in QTQT
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LPAI goes from a minimal site to multiple basic residues in HPAI... [shared file(s): image.png]