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Slack / Private Message Drop, p.1025 [SLACK_001239] · slack_pm:msg:10706

Page text: p.1025 · original PDF

Date
2021-11-24 08:24
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker
Andrew Rambaut

Recipients on this medium are inferred from channel membership, not per-message addressing.

Visited South Africa for 20 days - must be a much more prevalent virus than the sequencing suggests

In context

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  1. 2021-11-24 07:36 Kristian G. Andersen open
    Holy shit - that is quite something. The length of that branch... :scream:. What's the N/S on the branch?
  2. 2021-11-24 07:41 Kristian G. Andersen open
    Just had a look at the list of mutations - so nuts. Getting rid of a lot of serines (although also adding some new ones...) and adding in lysine - the friggin' genome is going to be made out of lysines at some point! Just nuts.
  3. 2021-11-24 08:22 Robert F. Garry open
    Oh boy - it's getting more polybasic - that's not good....
  4. 2021-11-24 08:23 Andrew Rambaut open
    It must surely be from a immunocompromised chronic infection. Possibly a dual infection with recombination and heavy mutation. But the random traveller in HK has me very worried
  5. 2021-11-24 08:24 Andrew Rambaut
    Visited South Africa for 20 days - must be a much more prevalent virus than the sequencing suggests
  6. 2021-11-24 08:24 Andrew Rambaut open
    Will cause S gene dropout and I think SA is seeing some signal of that apparently
  7. 2021-11-24 08:29 Kristian G. Andersen open
    HIV patient or animal reservoir - I'll say 70/30 odds.
  8. 2021-11-24 08:32 Kristian G. Andersen open
    Bob, presumably the N679K combined with P681H makes this a better FCS, correct? It's interesting to see E484A inthere too - presumably E484K was a bit too much.
  9. 2021-11-24 08:33 Kristian G. Andersen open
    I swear to god - if we see another monster variant gain territory here in November/December, something is driving the emergence. What, I don't know, but "something".

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