COVID-19 Records

Chat message

Slack / Private Message Drop, p.997 [SLACK_001211] · slack_pm:msg:10398

Page text: p.997 · original PDF

Date
2021-09-14 06:40
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry

Recipients on this medium are inferred from channel membership, not per-message addressing.

THe FCS will still be there but most likely not as good as P681R. Totally agree about the N501 S or D maybe non-human. That could be spillback followed I guess by another spillover..

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

  1. 2021-09-14 06:35 Andrew Rambaut open
    501D is interesting as it is in RaTG13 (i.e., one of the residues SC2 ancestors lost)
  2. 2021-09-14 06:36 Robert F. Garry open
    For completeness - here's P681R - as discussed previously it changes one of the O-linked glycans [shared file(s): image.png]
  3. 2021-09-14 06:36 Andrew Rambaut open
    The loss of furin cleavage and some RBD mutations seems like it might be non-human
  4. 2021-09-14 06:37 Andrew Rambaut open
    There are about 100 681S human genomes on GISAID and some evidence of transmission clusters so can't be a totally unfit virus in humans
  5. 2021-09-14 06:40 Robert F. Garry
    THe FCS will still be there but most likely not as good as P681R. Totally agree about the N501 S or D maybe non-human. That could be spillback followed I guess by another spillover..
  6. 2021-09-14 06:46 Kristian G. Andersen open
    That is a weirdly mutates spike... Often we see charge reversions, but that's not what's going on here - instead we see several hydroxyl groups? There are more S/T mutations in that spike than the two you mentioned. Novel receptor?
  7. 2021-09-14 06:52 Andrew Rambaut open
    This is highly confidential right now but it is from wastewater in a city. It has been frequently coming up over time and has not been seen in any of the human cases in the city (and as you know we do sequence a lot). We are speculating it is in rats or something.
  8. 2021-09-14 06:53 Andrew Rambaut open
    The good news is probably that this will be less fit in humans and is not a particular threat (above Delta which wealready have). Would be interesting though.
  9. 2021-09-14 06:56 Robert F. Garry open
    Very interesting!

Full conversation →