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1. 2021-09-14 06:40 Robert F. Garry open
   THe FCS will still be there but most likely not as good as P681R. Totally agree about the N501 S or D maybe non-human. That could be spillback followed I guess by another spillover..
2. 2021-09-14 06:46 Kristian G. Andersen open
   That is a weirdly mutates spike... Often we see charge reversions, but that's not what's going on here - instead we see several hydroxyl groups? There are more S/T mutations in that spike than the two you mentioned. Novel receptor?
3. 2021-09-14 06:52 Andrew Rambaut open
   This is highly confidential right now but it is from wastewater in a city. It has been frequently coming up over time and has not been seen in any of the human cases in the city (and as you know we do sequence a lot). We are speculating it is in rats or something.
4. 2021-09-14 06:53 Andrew Rambaut open
   The good news is probably that this will be less fit in humans and is not a particular threat (above Delta which wealready have). Would be interesting though.
5. 2021-09-14 06:56 Robert F. Garry
   Very interesting!
6. 2021-09-14 07:06 Kristian G. Andersen open
   Indeed - that is interesting. As you say, could likely be animals, but yes, probably not a concern in humans compared to delta.
7. 2021-09-14 07:06 Kristian G. Andersen open
   Don't rodent CoVs have funky FCSs? Question for Stephen...
8. 2021-09-14 07:30 Robert F. Garry open
   SLACK_001212 MHV changes its FCS all the time
9. 2021-09-14 07:30 Robert F. Garry open
   See here - no making fun of my tree. [shared file(s): image.png]

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