Slack / Private Message Drop — page 997

501D is interesting as it is in RaTG13 (i.e., one of the residues SC2 ancestors lost) [2021-09-14 06:36:54] [Robert Garry] For completeness - here's P681R - as discussed previously it changes one of the O-linked glycans [shared file(s): image.png] [2021-09-14 06:36:57] [Andrew Rambaut] The loss of furin cleavage and some RBD mutations seems like it might be non-human [2021-09-14 06:37:56] [Andrew Rambaut] There are about 100 681S human genomes on GISAID and some evidence of transmission clusters so can't be a totally unfit virus in humans [2021-09-14 06:40:52] [Robert Garry] THe FCS will still be there but most likely not as good as P681R. Totally agree about the N501 S or D maybe non-human. That could be spillback followed I guess by another spillover.. [2021-09-14 06:46:45] [Kristian Andersen] That is a weirdly mutates spike... Often we see charge reversions, but that's not what's going on here - instead we see several hydroxyl groups? There are more S/T mutations in that spike than the two you mentioned. Novel receptor? [2021-09-14 06:52:52] [Andrew Rambaut] This is highly confidential right now but it is from wastewater in a city. It has been frequently coming up over time and has not been seen in any of the human cases in the city (and as you know we do sequence a lot). We are speculating it is in rats or something. [2021-09-14 06:53:47] [Andrew Rambaut] The good news is probably that this will be less fit in humans and is not a particular threat (above Delta which we already have). Would be interesting though. [2021-09-14 06:56:54] [Robert Garry] Very interesting! [2021-09-14 07:06:12] [Kristian Andersen] Indeed - that is interesting. As you say, could likely be animals, but yes, probably not a concern in humans compared to delta. [2021-09-14 07:06:55] [Kristian Andersen] Don't rodent CoVs have funky FCSs? Question for Stephen... [2021-09-14 07:30:53] [Robert Garry]