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1. 2021-09-14 06:35 Andrew Rambaut open
   question is - does any of this spike profile make you think it might be in a non-human host?
2. 2021-09-14 06:35 Andrew Rambaut open
   501D is interesting as it is in RaTG13 (i.e., one of the residues SC2 ancestors lost)
3. 2021-09-14 06:36 Robert F. Garry open
   For completeness - here's P681R - as discussed previously it changes one of the O-linked glycans [shared file(s): image.png]
4. 2021-09-14 06:36 Andrew Rambaut open
   The loss of furin cleavage and some RBD mutations seems like it might be non-human
5. 2021-09-14 06:37 Andrew Rambaut
   There are about 100 681S human genomes on GISAID and some evidence of transmission clusters so can't be a totally unfit virus in humans
6. 2021-09-14 06:40 Robert F. Garry open
   THe FCS will still be there but most likely not as good as P681R. Totally agree about the N501 S or D maybe non-human. That could be spillback followed I guess by another spillover..
7. 2021-09-14 06:46 Kristian G. Andersen open
   That is a weirdly mutates spike... Often we see charge reversions, but that's not what's going on here - instead we see several hydroxyl groups? There are more S/T mutations in that spike than the two you mentioned. Novel receptor?
8. 2021-09-14 06:52 Andrew Rambaut open
   This is highly confidential right now but it is from wastewater in a city. It has been frequently coming up over time and has not been seen in any of the human cases in the city (and as you know we do sequence a lot). We are speculating it is in rats or something.
9. 2021-09-14 06:53 Andrew Rambaut open
   The good news is probably that this will be less fit in humans and is not a particular threat (above Delta which wealready have). Would be interesting though.

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