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Slack / Private Message Drop, p.882 [SLACK_001096] · slack_pm:msg:09145

Page text: p.882 · original PDF

Date
2021-05-27 13:38
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

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Well, fuck me - so obvious and honestly I had not thought about it. Yes, they should and yes that should be totallydoable.

In context

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  1. 2021-05-27 12:45 Kristian G. Andersen open
    And it's worth pointing out that this is strictly an academic question, not a public health one - it's clear 617 is aproblem and we need to act, but that was clear weeks ago.
  2. 2021-05-27 13:06 Andrew Rambaut open
    Just discussing that. My personal hunch has been that B117 is adapted to strong NPI by being more transmissible early but for shorter (causing more damage and thus severity). Make the most of limited number of contacts. 617.2may have a longer pre-symptom period making it better in a more free-for-all environment (i.e., unfortunate timing asUK restrictions have lifted).
  3. 2021-05-27 13:10 Kristian G. Andersen open
    Yeah, that's an interesting theory - although it seems like 117 may actually also infect for longer? Did Oli ever do anyof the modeling analyses to try and flesh these differences out a little more?
  4. 2021-05-27 13:34 Edward C. Holmes open
    I wonder if they have enough material to shotgun sequence the environmental samples from the market? Might tell them want animals were being sold my looking at the expressed host genes (e.g. COII). Doesn't even need to be the virus positive samples although they would be better.
  5. 2021-05-27 13:38 Kristian G. Andersen
    Well, fuck me - so obvious and honestly I had not thought about it. Yes, they should and yes that should be totallydoable.
  6. 2021-05-27 13:39 Andrew Rambaut open
    Could do a COI amplification - i.e., species barcoding?
  7. 2021-05-27 13:47 Edward C. Holmes open
    I'll see if I can get George and Weifeng to do it
  8. 2021-05-27 13:50 Kristian G. Andersen open
    Yeah, they should really get on it - metagenomic sequencing should be sufficient. It'll be messy, but not a lot of data needed to do meaningful IDs
  9. 2021-05-27 13:52 Andrew Rambaut open
    You sure you would be able to do species ID? Pretty unlikely to bring up anything with species level specificity

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