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Slack / Private Message Drop, p.781 [SLACK_000995] · slack_pm:msg:08144

Page text: p.781 · original PDF

Date
2021-05-11 21:43
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen
Topics
Gain-of-function researchLab-leak / accidental release hypothesisWuhan Institute of Virology collaboration

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As an aside - trying to dig into papers eDim and others describe as gain-of-function / GOF at WIV. This seems to bethe main (only?) one: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006698.VERY clearly not GOF as defined here (they don't do serial passage, they don't create the chimeric viruses to be"better pathogens", they're not SARS, MERS, or flu, etc., etc. - and the chimeric viruses actually bind worse tohuman receptors than wildtype):https://www.phe.gov/s3/dualuse/documents/gain-of-function.pdfhttps://www.phe.gov/s3/dualuse/documents/p3co.pdfIt's total BS.Just FYI since this might come up in random conversation...

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This seems to bethe main (only?) one: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006698.VERY clearly not GOF as defined here (they don't do serial passage, they don't create the chimeric viruses to be"better pathogens", they're not SARS, MERS, or flu, etc., etc. - and the chimeric viruses actually bind worse tohuman receptors than wildtype):https://www.phe.gov/s3/dualuse/documents/gain-of-function.pdfhttps://www.phe.gov/s3/dualuse/documents/p3co.pdfIt's total BS.Just FYI since this might come up in random conversation... quoted / not their view quoted_external sentence carries quotation marks questions

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  1. 2021-05-11 21:26 Edward C. Holmes open
    As an aside, if you look at the gamey tastes figure you will see that some of the pangolins sold as food were sick. We've just done some SRA mining and found that the found the famous data produced by Liu et al. in that Viruses papers of 2019 also contains a pestivirus. And you wonder why disease emergence events happen.
  2. 2021-05-11 21:43 Kristian G. Andersen
    As an aside - trying to dig into papers eDim and others describe as gain-of-function / GOF at WIV. This seems to bethe main (only?) one: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006698.VERY clearly not GOF as defined here (they don't do serial passage, they don't create the chimeric viruses to be"better pathogens", they're not SARS, MERS, or flu, etc., etc. - and the chimeric viruses actually bind worse tohuman receptors than wildtype):https://www.phe.gov/s3/dualuse/documents/gain-of-function.pdfhttps://www.phe.gov/s3/dualuse/documents/p3co.pdfIt's total BS.Just FYI since this might come up in random conversation...
  3. 2021-05-11 21:59 Edward C. Holmes open
    Yes, that's biodiversity. No way GOF.
  4. 2021-05-11 22:01 Kristian G. Andersen open
    They make chimeric viruses in the paper (small part), but still not GOF.
  5. 2021-05-11 22:05 Edward C. Holmes open
    Ah, got it.
  6. 2021-05-11 22:07 Edward C. Holmes open
    They emailed us!

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