Chat message

Slack / Private Message Drop, p.781 [SLACK_000995] · slack_pm:msg:08143

Date: 2021-05-11 21:26
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes
Topics: Natural origin / zoonotic spillover

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As an aside, if you look at the gamey tastes figure you will see that some of the pangolins sold as food were sick. We've just done some SRA mining and found that the found the famous data produced by Liu et al. in that Viruses papers of 2019 also contains a pestivirus. And you wonder why disease emergence events happen.

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Statement	Grade	Attribution	Stance
As an aside, if you look at the gamey tastes figure you will see that some of the pangolins sold as food were sick.	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

As an aside, if you look at the gamey tastes figure you will see that some of the pangolins sold as food were sick.

own voice, substantive

speaker_own

asserts

In context

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2021-05-11 21:26 Edward C. Holmes

As an aside, if you look at the gamey tastes figure you will see that some of the pangolins sold as food were sick. We've just done some SRA mining and found that the found the famous data produced by Liu et al. in that Viruses papers of 2019 also contains a pestivirus. And you wonder why disease emergence events happen.
2021-05-11 21:43 Kristian G. Andersen open

As an aside - trying to dig into papers eDim and others describe as gain-of-function / GOF at WIV. This seems to bethe main (only?) one: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006698.VERY clearly not GOF as defined here (they don't do serial passage, they don't create the chimeric viruses to be"better pathogens", they're not SARS, MERS, or flu, etc., etc. - and the chimeric viruses actually bind worse tohuman receptors than wildtype):https://www.phe.gov/s3/dualuse/documents/gain-of-function.pdfhttps://www.phe.gov/s3/dualuse/documents/p3co.pdfIt's total BS.Just FYI since this might come up in random conversation...
2021-05-11 21:59 Edward C. Holmes open

Yes, that's biodiversity. No way GOF.
2021-05-11 22:01 Kristian G. Andersen open

They make chimeric viruses in the paper (small part), but still not GOF.
2021-05-11 22:05 Edward C. Holmes open

Ah, got it.

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