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Slack / Private Message Drop, pp.774-775 · slack_pm:msg:08105

Page text: p.774, p.775 · original PDF

Date
2021-05-11 02:56 (hour precision)
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry
Topics
Natural origin / zoonotic spilloverLab-leak / accidental release hypothesisWHO and international investigationProximal Origin paperWuhan Institute of Virology collaborationGain-of-function research

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Wuhan wildlife markets suggests SARS-CoV-2 has a natural origin Robert F. Garry1.2 Introduction Our previous commentary on the Proximal Origins of SARS-CoV-2 (Andersen et al., 2020) concluded that, "SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus (Andersen et al., 2020)." The possibility of a laboratory release or Lab Leak was also considered, but it was determined that a natural origin ofSARS-CoV-2 is much more likely. Recently, a team of scientists under the auspices of the World Health Organization (WHO) reached similar conclusions (WHO Report, 2021). Other groups have speculated that SARS-CoV-2 may be the result of undisclosed research on SARS-CoV-2 or a close progenitor and accidental release [Relman, 2020; Parisite 1, 2]. Some Lab Leak proponents have suggested that SARS-Cov-2 may be the product of laboratory passage of a progenitor virus in cell culture or animals, or Gain-of-Function research [ref]. New data presented by the WHO study provides clear findings in support of the Natural origin of SARS-CoV-2. Results The study of SARS-CoV-2 origins conducted by the WHO team provided important new data regarding the role ofwildlife markets in the emergence of SARS-CoV-2. The large Huanan seafood market, which also sold wildlife and wildlife products, was a focus of early attention because it was linked to the majority of early cases of COVID-19 inWuhan. The WHO report documented that early cases were not only linked to the Huanan market, but that other early cases were linked to different markets that sold wildlife or wildlife products. Among the first 168 diagnosedcases of COVID-19 in Wuhan with onset date prior to December 31, 2019 and a known history of exposure towildlife markets 55.4% (93/168) reported such exposures. Of the 168 cases, 28% (47/168) had only been to the Huanan market, 22% (38/168) had exposure to another wildlife market and 4.7% (8/168) had exposure to the Huanan market and another market (ref table). The genetic lineages of SARS-CoV-2 associated with early cases in Wuhan were documented in the WHO report. Previously, Rambaut et al, (2020) noted that at the root of the phylogeny of SARS-CoV-2 are two lineagesdesignated lineage A and B. Early lineage A viruses, include SARS-Cov-2 isolate EPI_ISL_529213 sampled on30Dec19 from a person linked to a wildlife market different than the Huanan market (Table 7, S13, WHO report2021). Linage A viruses share two nucleotides (T8,782 in ORF1ab and C28,144 in ORF8) with the bat viruses RaTG13 and RmYN02 and other sarbecoviruses. It is likely that the most recent common ancestor (MRCA) ofSARS-CoV-2 shares the same genome sequence as these early lineage A sequences (Rambaut et al., 2020).Different nucleotides (C8,782 in ORF1ab and T28,144 in ORF8) are present at those sites in viruses assigned tolineage B, such as SARS-CoV-2 isolate Wuhan-Hu-1 (GenBank accession no. MN908947, Table 7, S13, WHO report,) sampled from the Huanan market on 30Dec19. All virus positive samples from the Huanan market, fromvenders or customers of the market or from environmental samples, contained SARS-CoV-2 of lineage B. There was limited genetic diversity in the lineage B samples from the Huanan market, which is consistent with the marketas a site of a super-spreader event. Lineage A and Lineage B viruses spread throughout Wuhan and to other countries [ref]. [shared file(s): image.png, image.png]

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

StatementGradeAttributionStance
Wuhan wildlife markets suggests SARS-CoV-2 has a natural origin Robert F. quoted / not their view quoted_external message body appears to be pasted content asserts
Garry1.2 Introduction Our previous commentary on the Proximal Origins of SARS-CoV-2 (Andersen et al., 2020) concluded that, "SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus (Andersen et al., 2020)." The possibility of a laboratory release or Lab Leak was also considered, but it was determined that a natural origin ofSARS-CoV-2 is much more likely. quoted / not their view quoted_external sentence carries quotation marks asserts
Other groups have speculated that SARS-CoV-2 may be the result of undisclosed research on SARS-CoV-2 or a close progenitor and accidental release [Relman, 2020; Parisite 1, 2]. quoted / not their view quoted_external message body appears to be pasted content asserts
Some Lab Leak proponents have suggested that SARS-Cov-2 may be the product of laboratory passage of a progenitor virus in cell culture or animals, or Gain-of-Function research [ref]. quoted / not their view quoted_external message body appears to be pasted content asserts
The large Huanan seafood market, which also sold wildlife and wildlife products, was a focus of early attention because it was linked to the majority of early cases of COVID-19 inWuhan. quoted / not their view quoted_external message body appears to be pasted content asserts
The WHO report documented that early cases were not only linked to the Huanan market, but that other early cases were linked to different markets that sold wildlife or wildlife products. quoted / not their view quoted_external message body appears to be pasted content asserts
Of the 168 cases, 28% (47/168) had only been to the Huanan market, 22% (38/168) had exposure to another wildlife market and 4.7% (8/168) had exposure to the Huanan market and another market (ref table). quoted / not their view quoted_external message body appears to be pasted content asserts
There was limited genetic diversity in the lineage B samples from the Huanan market, which is consistent with the marketas a site of a super-spreader event. quoted / not their view quoted_external message body appears to be pasted content asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

  1. 2021-05-11 02:56 Robert F. Garry open
    @Eddie Holmes It's really something - yeah Jon publish it. [shared file(s): image.png]
  2. 2021-05-11 02:56 Robert F. Garry open
    @Eddie Holmes A random thought - why is eDim not a signer of RelBloomshit? Going direct at NIH OD Collins maybe too radical? Any journo that really wanted to sink in teeth would find the motherload. [shared file(s): image.png]
  3. 2021-05-11 02:56 Robert F. Garry open
    "We should show the same determination in promoting a dispassionate science-based discourse on this difficult but important issue." They want a determined but dispassionate science-based discourse on the topic that WIV was doing GoF research with the CCP army on a secret progenitor of SC2. Like I said this is starting to really piss me off.I may put my scenario diagrams up on virological.
  4. 2021-05-11 02:56 Robert F. Garry open
    @Eddie Holmes https:/(www.rawstory.com/rand-paul-vs-anthony-fauci-hearing-2652950727/?utm_source=push_notifications It's getting hot out there!
  5. 2021-05-11 02:56 Robert F. Garry
    Wuhan wildlife markets suggests SARS-CoV-2 has a natural origin Robert F. Garry1.2 Introduction Our previous commentary on the Proximal Origins of SARS-CoV-2 (Andersen et al., 2020) concluded that, "SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus (Andersen et al., 2020)." The possibility of a laboratory release or Lab Leak was also considered, but it was determined that a natural origin ofSARS-CoV-2 is much more likely. Recently, a team of scientists under the auspices of the World Health Organization (WHO) reached similar conclusions (WHO Report, 2021). Other groups have speculated that SARS-CoV-2 may be the result of undisclosed research on SARS-CoV-2 or a close progenitor and accidental release [Relman, 2020; Parisite 1, 2]. Some Lab Leak proponents have suggested that SARS-Cov-2 may be the product of laboratory passage of a progenitor virus in cell culture or animals, or Gain-of-Function research [ref]. New data presented by the WHO study provides clear findings in support of the Natural origin of SARS-CoV-2. Results The study of SARS-CoV-2 origins conducted by the WHO team provided important new data regarding the role ofwildlife markets in the emergence of SARS-CoV-2. The large Huanan seafood market, which also sold wildlife and wildlife products, was a focus of early attention because it was linked to the majority of early cases of COVID-19 inWuhan. The WHO report documented that early cases were not only linked to the Huanan market, but that other early cases were linked to different markets that sold wildlife or wildlife products. Among the first 168 diagnosedcases of COVID-19 in Wuhan with onset date prior to December 31, 2019 and a known history of exposure towildlife markets 55.4% (93/168) reported such exposures. Of the 168 cases, 28% (47/168) had only been to the Huanan market, 22% (38/168) had exposure to another wildlife market and 4.7% (8/168) had exposure to the Huanan market and another market (ref table). The genetic lineages of SARS-CoV-2 associated with early cases in Wuhan were documented in the WHO report. Previously, Rambaut et al, (2020) noted that at the root of the phylogeny of SARS-CoV-2 are two lineagesdesignated lineage A and B. Early lineage A viruses, include SARS-Cov-2 isolate EPI_ISL_529213 sampled on30Dec19 from a person linked to a wildlife market different than the Huanan market (Table 7, S13, WHO report2021). Linage A viruses share two nucleotides (T8,782 in ORF1ab and C28,144 in ORF8) with the bat viruses RaTG13 and RmYN02 and other sarbecoviruses. It is likely that the most recent common ancestor (MRCA) ofSARS-CoV-2 shares the same genome sequence as these early lineage A sequences (Rambaut et al., 2020).Different nucleotides (C8,782 in ORF1ab and T28,144 in ORF8) are present at those sites in viruses assigned tolineage B, such as SARS-CoV-2 isolate Wuhan-Hu-1 (GenBank accession no. MN908947, Table 7, S13, WHO report,) sampled from the Huanan market on 30Dec19. All virus positive samples from the Huanan market, fromvenders or customers of the market or from environmental samples, contained SARS-CoV-2 of lineage B. There was limited genetic diversity in the lineage B samples from the Huanan market, which is consistent with the marketas a site of a super-spreader event. Lineage A and Lineage B viruses spread throughout Wuhan and to other countries [ref]. [shared file(s): image.png, image.png]

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