A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
-
Yes - indeed! Also RpYN06 and PRC31 are essentially GD pango in the NTD so the important bits are definitely out there! [shared file(s): image.png]
-
Have been meaning to put this expanded alignment up as a supplement to Holmes 2021 - should do that at some point.
-
Very interesting. I'll see if any more pangolin viruses are on the go.
-
Looking at it this way you can see the relationships in the sarbecos pretty clearly. [shared file(s): image.png]
-
2021-04-13 14:41
Robert F. Garry
@Eddie Holmes On it! But hopefully others are as well.
-
Really interesting but I haven't fully got my head around it - basically it means that the bat-like NTD is sub-optimal for humans, B.1.1.7 has converged on whatever the pangolin has as an adaptation to humans (given that B.1.1.7 is the most human adapted virus yet).
-
So 69-70 deletion and the 144 deletion provide greater infectivity (and presumably when combined with 501Y RBD and 681H furin site) result in higher transmissibility.
-
Other thing I got today was that the 3 nucleotide mutation in the middle of N that arose in the early Italian lineage probably create a new sgRNA - the resulting nucleotide sequence is complementary to the sgRNA transcriptionleader at the 5' end. That 3 nucleotide mutation had been bugging me for ages.
-
The cool thing is that explains the N:D3L (also a 3 nucleotide mutation) in B.1.1.7 - Sheffield showed this probably enhances the recombination with the leader two - so it may be compensating to create more N