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Slack / Private Message Drop, p.699 [SLACK_000913] · slack_pm:msg:07334

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Very interesting. I'll see if any more pangolin viruses are on the go.

Extracted statements

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Statement	Grade	Attribution	Stance
I'll see if any more pangolin viruses are on the go.	needs context	speaker_own	asserts

Statement

Grade

Attribution

Stance

I'll see if any more pangolin viruses are on the go.

needs context

speaker_own

asserts

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-04-13 14:26 Edward C. Holmes open

eDim ain't gonna like those experiments!
2021-04-13 14:27 Edward C. Holmes open

Sounds like we ought to be looking for more pango viruses?
2021-04-13 14:33 Robert F. Garry open

Yes - indeed! Also RpYN06 and PRC31 are essentially GD pango in the NTD so the important bits are definitely out there! [shared file(s): image.png]
2021-04-13 14:35 Robert F. Garry open

Have been meaning to put this expanded alignment up as a supplement to Holmes 2021 - should do that at some point.
2021-04-13 14:39 Edward C. Holmes

Very interesting. I'll see if any more pangolin viruses are on the go.
2021-04-13 14:40 Robert F. Garry open

Looking at it this way you can see the relationships in the sarbecos pretty clearly. [shared file(s): image.png]
2021-04-13 14:41 Robert F. Garry open

@Eddie Holmes On it! But hopefully others are as well.
2021-04-13 14:42 Andrew Rambaut open

Really interesting but I haven't fully got my head around it - basically it means that the bat-like NTD is sub-optimal for humans, B.1.1.7 has converged on whatever the pangolin has as an adaptation to humans (given that B.1.1.7 is the most human adapted virus yet).
2021-04-13 14:45 Andrew Rambaut open

So 69-70 deletion and the 144 deletion provide greater infectivity (and presumably when combined with 501Y RBD and 681H furin site) result in higher transmissibility.