Slack / Private Message Drop — page 699

[Andrew Rambaut] @Robert Garry Cited your indel regions as likely reason [2021-04-13 14:22:46] [Andrew Rambaut] Will see if he has a preprint or something. [2021-04-13 14:24:23] [Robert Garry] :+1: brilliant [2021-04-13 14:26:15] [Eddie Holmes] eDim ain't gonna like those experiments! [2021-04-13 14:27:34] [Eddie Holmes] [thread - ID: 2021-04-13 14:27:34] Sounds like we ought to be looking for more pango viruses? [2021-04-13 14:33:23] [Robert Garry] Yes - indeed! Also RpYN06 and PRC31 are essentially GD pango in the NTD so the important bits are definitely out there! [shared file(s): image.png] [2021-04-13 14:35:45] [Robert Garry] Have been meaning to put this expanded alignment up as a supplement to Holmes 2021 - should do that at some point. [2021-04-13 14:39:12] [Eddie Holmes] Very interesting. I'll see if any more pangolin viruses are on the go. [2021-04-13 14:40:35] [Robert Garry] Looking at it this way you can see the relationships in the sarbecos pretty clearly. [shared file(s): image.png] [2021-04-13 14:41:54] [Robert Garry] [thread - ID: 2021-04-13 14:27:34] @Eddie Holmes On it! But hopefully others are as well. [2021-04-13 14:42:54] [Andrew Rambaut] Really interesting but I haven't fully got my head around it - basically it means that the bat-like NTD is sub-optimal for humans, B.1.1.7 has converged on whatever the pangolin has as an adaptation to humans (given that B.1.1.7 is the most human adapted virus yet). [2021-04-13 14:45:16] [Andrew Rambaut] So 69-70 deletion and the 144 deletion provide greater infectivity (and presumably when combined with 501Y RBD and 681H furin site) result in higher transmissibility. [2021-04-13 14:49:56]