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Slack / Private Message Drop, p.699 [SLACK_000913] · slack_pm:msg:07335

Page text: p.699 · original PDF

Date
2021-04-13 14:40
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry

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Looking at it this way you can see the relationships in the sarbecos pretty clearly. [shared file(s): image.png]

In context

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  1. 2021-04-13 14:27 Edward C. Holmes open
    Sounds like we ought to be looking for more pango viruses?
  2. 2021-04-13 14:33 Robert F. Garry open
    Yes - indeed! Also RpYN06 and PRC31 are essentially GD pango in the NTD so the important bits are definitely out there! [shared file(s): image.png]
  3. 2021-04-13 14:35 Robert F. Garry open
    Have been meaning to put this expanded alignment up as a supplement to Holmes 2021 - should do that at some point.
  4. 2021-04-13 14:39 Edward C. Holmes open
    Very interesting. I'll see if any more pangolin viruses are on the go.
  5. 2021-04-13 14:40 Robert F. Garry
    Looking at it this way you can see the relationships in the sarbecos pretty clearly. [shared file(s): image.png]
  6. 2021-04-13 14:41 Robert F. Garry open
    @Eddie Holmes On it! But hopefully others are as well.
  7. 2021-04-13 14:42 Andrew Rambaut open
    Really interesting but I haven't fully got my head around it - basically it means that the bat-like NTD is sub-optimal for humans, B.1.1.7 has converged on whatever the pangolin has as an adaptation to humans (given that B.1.1.7 is the most human adapted virus yet).
  8. 2021-04-13 14:45 Andrew Rambaut open
    So 69-70 deletion and the 144 deletion provide greater infectivity (and presumably when combined with 501Y RBD and 681H furin site) result in higher transmissibility.
  9. 2021-04-13 14:49 Andrew Rambaut open
    Other thing I got today was that the 3 nucleotide mutation in the middle of N that arose in the early Italian lineage probably create a new sgRNA - the resulting nucleotide sequence is complementary to the sgRNA transcriptionleader at the 5' end. That 3 nucleotide mutation had been bugging me for ages.

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