Chat message

Slack / Private Message Drop, p.590 [SLACK_000804] · slack_pm:msg:06167

Date: 2021-03-12 13:05
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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Here's the updated Fig. 1 with the new bat viruses. Also noticed that a few of the new ones have a concentration ofS,T,P around the S1/S2 junction. Interestingly, several have several predicted O-linked glycans. So that's a featureof the site that is independent of the SC2 FCS itself. Also worth noting the O-linked glycans near the N terminus aswell. [shared file(s): image.png]

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2021-03-12 12:33 Edward C. Holmes open

You're right! I had better stick to coffee...oh no, civets shit coffee beans!!!
2021-03-12 12:38 Edward C. Holmes open

I post this because it is pretty instructive.
2021-03-12 12:51 Robert F. Garry open

Also consistent with another conspiracy theory - all the world's leading virologists (and a few politicians) areshape-shifting space aliens from the future.
2021-03-12 12:56 Robert F. Garry open

It's really the only way to explain QTQTNS and some of the other spike motifs in newly sequenced Bat CoVs.
2021-03-12 13:05 Robert F. Garry

Here's the updated Fig. 1 with the new bat viruses. Also noticed that a few of the new ones have a concentration ofS,T,P around the S1/S2 junction. Interestingly, several have several predicted O-linked glycans. So that's a featureof the site that is independent of the SC2 FCS itself. Also worth noting the O-linked glycans near the N terminus aswell. [shared file(s): image.png]
2021-03-12 13:10 Edward C. Holmes open

Great stuff Bob. I've just sent you the SI files.
2021-03-12 13:31 Edward C. Holmes open

Shouldn't forget this stuff either: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5241a2.htm
2021-03-12 13:43 Robert F. Garry open

THANKS -yeah the serosurveys are VERY important. Koopmans was on NBC news last night for an interview and they were "grilling" her about the supposed flu-like cases that were at WIV in Fall 2019. She said they were antibody negative - a big nothing, but grist for Fox News and Pompeo.
2021-03-12 13:46 Edward C. Holmes open

Ha. What a surprise

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