Slack / Private Message Drop — page 590

[thread - ID: 2021-03-12 09:01:39] I post this because it is pretty instructive. [2021-03-12 12:51:48] [Robert Garry] Also consistent with another conspiracy theory - all the world's leading virologists (and a few politicians) are shape-shifting space aliens from the future. [2021-03-12 12:56:55] [Robert Garry] It's really the only way to explain QTQTNS and some of the other spike motifs in newly sequenced Bat CoVs. [2021-03-12 13:05:25] [Robert Garry] Here's the updated Fig. 1 with the new bat viruses. Also noticed that a few of the new ones have a concentration of S,T,P around the S1/S2 junction. Interestingly, several have several predicted O-linked glycans. So that's a feature of the site that is independent of the SC2 FCS itself. Also worth noting the O-linked glycans near the N terminus as well. [shared file(s): image.png] [2021-03-12 13:10:37] [Eddie Holmes] Great stuff Bob. I've just sent you the SI files. [2021-03-12 13:31:48] [Eddie Holmes] Shouldn't forget this stuff either: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5241a2.htm [2021-03-12 13:43:00] [Robert Garry] THANKS -yeah the serosurveys are VERY important. Koopmans was on NBC news last night for an interview and they were "grilling" her about the supposed flu-like cases that were at WIV in Fall 2019. She said they were antibody negative - a big nothing, but grist for Fox News and Pompeo. [2021-03-12 13:46:22] [Eddie Holmes] Ha. What a surprise [2021-03-12 13:47:53] [Robert Garry] And this: I do think Koopmans all by herself will make the Parisites look like the fools that they are. [shared file(s): image.png] [2021-03-12 14:42:26] [Eddie Holmes] Interesting. Bring that report on. [2021-03-12 16:42:10] [Robert Garry] Partly revised Fig 2 incorporating the new viruses from Weifeng and CRP31. Easy reference to see how similar GD pango is the RpYN06 and CPR31 in the NTD. Beyond that - I think it suggests that just like the RBD and S1/S2 inserts are bringing functionality (binding ACE2, affecting cleavage), I think the NTD inserts are doing the "something." [shared file(s): image.png] [2021-03-12 18:09:46] [Kristian Andersen]