COVID-19 Records

Chat message

Slack / Private Message Drop, p.542 [SLACK_000756] · slack_pm:msg:05645

Page text: p.542 · original PDF

Date
2021-02-23 00:10
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker
Edward C. Holmes

Recipients on this medium are inferred from channel membership, not per-message addressing.

Fascinating. So, D614G or Q613H (and perhaps linked mutations) push the virus down a particular evolutionary 'corridor' which then means that only certain subsequent mutations will follow?

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

  1. 2021-02-22 23:37 Edward C. Holmes open
    Can I just loop back to an earlier chat: @Andrew Rambaut in A.23.1 (Uganda I think) I assume you don't see Doug and Phil (the mutation in nsp12)? So, the elevated number of changes in this lineage is due to a different evolutionary pathway facilitated by another 'enabling' mutation like Doug (or Phil)? Do you see mutations that arestructurally/functionally similar to Doug and Phil? I'm just wondering if this parallel evolutionary process provides some important clues?
  2. 2021-02-23 00:03 Andrew Rambaut open
    It doesn't have Doug but it does have his brother Q613H. No Phil (a minority of them have nsp12 mutations but haven't dug into those yet). Does also have a bunch of NSP6 mutations in similar places to the deletion.
  3. 2021-02-23 00:05 Andrew Rambaut open
    Also I have had some backtracking about the P323L coming up in monkeys - data looks dodgy apparently.
  4. 2021-02-23 00:07 Andrew Rambaut open
    A.23.1 also has a cluster in the UK with E484K
  5. 2021-02-23 00:10 Edward C. Holmes
    Fascinating. So, D614G or Q613H (and perhaps linked mutations) push the virus down a particular evolutionary 'corridor' which then means that only certain subsequent mutations will follow?
  6. 2021-02-23 00:18 Andrew Rambaut open
    Interestingly it seems that P681R arose after Q613H: [shared file(s): A.23.1_2021-02-02.tree.png]
  7. 2021-02-23 00:25 Edward C. Holmes open
    Ha. So that parallels P681H in B.1.1.7?
  8. 2021-02-23 00:41 Edward C. Holmes open
    Reminds me of this: https://science.sciencemag.org/content/328/5983/1272

Full conversation →