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Slack / Private Message Drop, p.541 [SLACK_000755] · slack_pm:msg:05641

Date: 2021-02-22 23:37
Type: chat message · slack
mentioned: Andrew Rambaut
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes

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Can I just loop back to an earlier chat: @Andrew Rambaut in A.23.1 (Uganda I think) I assume you don't see Doug and Phil (the mutation in nsp12)? So, the elevated number of changes in this lineage is due to a different evolutionary pathway facilitated by another 'enabling' mutation like Doug (or Phil)? Do you see mutations that arestructurally/functionally similar to Doug and Phil? I'm just wondering if this parallel evolutionary process provides some important clues?

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2021-02-22 23:37 Edward C. Holmes

Can I just loop back to an earlier chat: @Andrew Rambaut in A.23.1 (Uganda I think) I assume you don't see Doug and Phil (the mutation in nsp12)? So, the elevated number of changes in this lineage is due to a different evolutionary pathway facilitated by another 'enabling' mutation like Doug (or Phil)? Do you see mutations that arestructurally/functionally similar to Doug and Phil? I'm just wondering if this parallel evolutionary process provides some important clues?
2021-02-23 00:03 Andrew Rambaut open

It doesn't have Doug but it does have his brother Q613H. No Phil (a minority of them have nsp12 mutations but haven't dug into those yet). Does also have a bunch of NSP6 mutations in similar places to the deletion.
2021-02-23 00:05 Andrew Rambaut open

Also I have had some backtracking about the P323L coming up in monkeys - data looks dodgy apparently.
2021-02-23 00:07 Andrew Rambaut open

A.23.1 also has a cluster in the UK with E484K
2021-02-23 00:10 Edward C. Holmes open

Fascinating. So, D614G or Q613H (and perhaps linked mutations) push the virus down a particular evolutionary 'corridor' which then means that only certain subsequent mutations will follow?

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