COVID-19 Records

Chat message

Slack / Private Message Drop, p.542 [SLACK_000756] · slack_pm:msg:05646

Page text: p.542 · original PDF

Date
2021-02-23 00:18
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker
Andrew Rambaut

Recipients on this medium are inferred from channel membership, not per-message addressing.

Interestingly it seems that P681R arose after Q613H: [shared file(s): A.23.1_2021-02-02.tree.png]

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

  1. 2021-02-23 00:03 Andrew Rambaut open
    It doesn't have Doug but it does have his brother Q613H. No Phil (a minority of them have nsp12 mutations but haven't dug into those yet). Does also have a bunch of NSP6 mutations in similar places to the deletion.
  2. 2021-02-23 00:05 Andrew Rambaut open
    Also I have had some backtracking about the P323L coming up in monkeys - data looks dodgy apparently.
  3. 2021-02-23 00:07 Andrew Rambaut open
    A.23.1 also has a cluster in the UK with E484K
  4. 2021-02-23 00:10 Edward C. Holmes open
    Fascinating. So, D614G or Q613H (and perhaps linked mutations) push the virus down a particular evolutionary 'corridor' which then means that only certain subsequent mutations will follow?
  5. 2021-02-23 00:18 Andrew Rambaut
    Interestingly it seems that P681R arose after Q613H: [shared file(s): A.23.1_2021-02-02.tree.png]
  6. 2021-02-23 00:25 Edward C. Holmes open
    Ha. So that parallels P681H in B.1.1.7?
  7. 2021-02-23 00:41 Edward C. Holmes open
    Reminds me of this: https://science.sciencemag.org/content/328/5983/1272

Full conversation →