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Slack / Private Message Drop, p.527 [SLACK_000741] · slack_pm:msg:05491

Page text: p.527 · original PDF

Date
2021-02-19 13:34
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

https://nextstrain.org/ncov/global?c=gt-ORF1b_314

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  1. 2021-02-19 13:27 Kristian G. Andersen open
    ORF1b P314L? Interesting - pretty much defines Doug...
  2. 2021-02-19 13:31 Robert F. Garry open
    Yeah - DouG literally opened up the stem but the nsp12 mutation may be affecting polymerase fidelity (surprising if itdidn't). Could be why @Eddie Holmes reports the volutility in trying to grow postDouG variants in cell culture.
  3. 2021-02-19 13:32 Robert F. Garry open
    P323L I think.
  4. 2021-02-19 13:34 Kristian G. Andersen open
    Here's Nextstrain - 323 is listed as only "K". [shared file(s): Screen Shot 2021-02-19 at 1.33.44 PM.png]
  5. 2021-02-19 13:34 Kristian G. Andersen
    https://nextstrain.org/ncov/global?c=gt-ORF1b_314
  6. 2021-02-19 14:17 Robert F. Garry open
    Yeah -that it... It's DouG's world but his naughty polymerase girlfriend PearL may be causing a lot of disruption onher own.
  7. 2021-02-19 14:26 Kristian G. Andersen open
    You know - none of these spike mutations may make SARS-CoV-2 more transmissible...
  8. 2021-02-19 14:30 Robert F. Garry open
    You could be right - Thinking back and Bob C and Tom Geisbert will know better, but I think that all of the mutations that make LASV replicate in guinea pigs are in polymerase.
  9. 2021-02-19 14:34 Kristian G. Andersen open
    I believe in flu, the polymerase is key too.

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