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Slack / Private Message Drop, p.527 [SLACK_000741] · slack_pm:msg:05494

Date: 2021-02-19 14:30
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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You could be right - Thinking back and Bob C and Tom Geisbert will know better, but I think that all of the mutations that make LASV replicate in guinea pigs are in polymerase.

In context

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2021-02-19 13:34 Kristian G. Andersen open

Here's Nextstrain - 323 is listed as only "K". [shared file(s): Screen Shot 2021-02-19 at 1.33.44 PM.png]
2021-02-19 13:34 Kristian G. Andersen open

https://nextstrain.org/ncov/global?c=gt-ORF1b_314
2021-02-19 14:17 Robert F. Garry open

Yeah -that it... It's DouG's world but his naughty polymerase girlfriend PearL may be causing a lot of disruption onher own.
2021-02-19 14:26 Kristian G. Andersen open

You know - none of these spike mutations may make SARS-CoV-2 more transmissible...
2021-02-19 14:30 Robert F. Garry

You could be right - Thinking back and Bob C and Tom Geisbert will know better, but I think that all of the mutations that make LASV replicate in guinea pigs are in polymerase.
2021-02-19 14:34 Kristian G. Andersen open

I believe in flu, the polymerase is key too.
2021-02-19 14:38 Robert F. Garry open

Exactly!
2021-02-19 14:39 Robert F. Garry open

Although occasionally a little FCS can get involved in the fun.
2021-02-19 14:45 Andrew Rambaut open

I heard from a confidential source that in macaque infections P323L (Phil) came up in 10/10 monkeys.

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