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Slack / Private Message Drop, pp.526-527 [SLACK_000740] · slack_pm:msg:05487

Page text: p.526, p.527 · original PDF

Date
2021-02-19 13:27
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

ORF1b P314L? Interesting - pretty much defines Doug...

In context

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  1. 2021-02-19 12:35 Robert F. Garry open
    Same feeling I got when I saw the PRRA....
  2. 2021-02-19 12:47 Robert F. Garry open
    Looks like it showed up early around about the time of the first DouG sightings.
  3. 2021-02-19 13:12 Kristian G. Andersen open
    What's the coordinates of that mutation in ORF1a space Bob?
  4. 2021-02-19 13:24 Robert F. Garry open
    I think it's C14408T P4715L.
  5. 2021-02-19 13:27 Kristian G. Andersen
    ORF1b P314L? Interesting - pretty much defines Doug...
  6. 2021-02-19 13:31 Robert F. Garry open
    Yeah - DouG literally opened up the stem but the nsp12 mutation may be affecting polymerase fidelity (surprising if itdidn't). Could be why @Eddie Holmes reports the volutility in trying to grow postDouG variants in cell culture.
  7. 2021-02-19 13:32 Robert F. Garry open
    P323L I think.
  8. 2021-02-19 13:34 Kristian G. Andersen open
    Here's Nextstrain - 323 is listed as only "K". [shared file(s): Screen Shot 2021-02-19 at 1.33.44 PM.png]
  9. 2021-02-19 13:34 Kristian G. Andersen open
    https://nextstrain.org/ncov/global?c=gt-ORF1b_314

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