Chat message

Slack / Private Message Drop, p.495 [SLACK_000709] · slack_pm:msg:05170

Date: 2021-02-07 12:26
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen
Topics: Vaccines

Recipients on this medium are inferred from channel membership, not per-message addressing.

Absolutely no effect preventing mild-moderate so I don't expect much ability to prevent severe either. But we'll see -this is very early data. It's just a shit vaccine - I'm sure the others won't see this bad a drop (and we have _some_ data on that) and will also prevent severe disease in many cases.

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Statement	Grade	Attribution	Stance
It's just a shit vaccine - I'm sure the others won't see this bad a drop (and we have _some_ data on that) and will also prevent severe disease in many cases.	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

It's just a shit vaccine - I'm sure the others won't see this bad a drop (and we have _some_ data on that) and will also prevent severe disease in many cases.

own voice, substantive

speaker_own

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-02-07 12:17 Kristian G. Andersen open

This is pretty nuts - AZN/Oxford vaccine totally killed by B.1.351. Not good. (and do we need to go back to consider that strange overlap between all these variants and the vax trials? Probably not, but it makes me uncomfortable).https://twitter.com/EricTopol/status/1358488910637060097?s=20
2021-02-07 12:22 Andrew Rambaut open

I think the big question is is this E484K or is it a combo with something else. E484K is popping up all over the shopat the moment.
2021-02-07 12:23 Robert F. Garry open

Also mild-moderate disease - more important how about severe?
2021-02-07 12:25 Kristian G. Andersen open

I think Leif and Karen are key too - but I'd expect B.1.1.7 + Erik to come with a big hit too.
2021-02-07 12:26 Kristian G. Andersen

Absolutely no effect preventing mild-moderate so I don't expect much ability to prevent severe either. But we'll see -this is very early data. It's just a shit vaccine - I'm sure the others won't see this bad a drop (and we have _some_ data on that) and will also prevent severe disease in many cases.
2021-02-07 12:28 Andrew Rambaut open

Leif is everywhere (and quite common on B.1.1.7)
2021-02-07 12:29 Andrew Rambaut open

When testing vaccines against B.1.351, are they using one with Leif and Karen?
2021-02-07 12:29 Andrew Rambaut open

Or the serum - do they know the genotype of the donor?
2021-02-07 12:30 Robert F. Garry open

https://docs.google.com/document/d/17-2hi7-fNsjE44himeCkm1PoZ7_-ncvpxUlhShZzDCU/edit On another note - I just popped a *nearly clean draft* of a proposed Virological post about Cambodian, Thai and Japanese bat sarbecoviruses. It's actually pretty mild, but Alina etc. *do* get attention. I borrowed VERY heavily from this channel,so please let me know if you are co-authors or I can go solo...

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