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Slack / Private Message Drop, p.475 [SLACK_000689] · slack_pm:msg:04932

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Fascinating - I dunno, but short copy-choice error events - 3, 6, 9, 12 bases at a time?

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-02-02 15:16 Robert F. Garry open

AndreW mutations would be among the rarest of all. You might ask why. Except for Methionine [it's special too] Tryptophan is the only aa with a single codon: UGG. For AndreW - You need to change the first two bases of an Alanine codon GCU, GCC, GCA, or GCG and generally all three. But, you really need to want to put in the tryptophan codon UGG because close relatives UAG and UGA are stop codons. Stop codons in viral proteins are bad. If that region mutates "slightly" it's a stop and a dead virus. That's what makes this sequence: WPWYIW which happens to be prior to the SC2 TM domain special too.
2021-02-02 15:19 Andrew Rambaut open

Although interestingly the D3L mutation in N in B.1.1.7 is a complete codon change GAT->CTA
2021-02-02 15:20 Andrew Rambaut open

As @Kristian Andersen said - this virus is weird
2021-02-02 15:23 Robert F. Garry

Fascinating - I dunno, but short copy-choice error events - 3, 6, 9, 12 bases at a time?
2021-02-02 16:00 Robert F. Garry open

Only in New Orleans: https://www.bing.com/videos/search?q=3+6+9+the+monkey+drank+wine&view=detail&a mp;mid=36[...]4N1480D022419AA6B84BBD86%26form%3dCONBDF%26conlogo%3dCT3210127
2021-02-02 16:05 Robert F. Garry open

You may want to watch the version from the Rebelles too...
2021-02-02 16:06 Robert F. Garry open

I think Frenchie and LuLu might have a little thing going...