Private channel session 909

7 messages over 50m, 2021-02-02 – 2021-02-02.

A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.

1. 2021-02-02 15:16 Robert F. Garry open PDF p.474
   AndreW mutations would be among the rarest of all. You might ask why. Except for Methionine [it's special too] Tryptophan is the only aa with a single codon: UGG. For AndreW - You need to change the first two bases of an Alanine codon GCU, GCC, GCA, or GCG and generally all three. But, you really need to want to put in the tryptophan codon UGG because close relatives UAG and UGA are stop codons. Stop codons in viral proteins are bad. If that region mutates "slightly" it's a stop and a dead virus. That's what makes this sequence: WPWYIW which happens to be prior to the SC2 TM domain special too.
2. 2021-02-02 15:19 Andrew Rambaut open PDF p.475
   Although interestingly the D3L mutation in N in B.1.1.7 is a complete codon change GAT->CTA
3. 2021-02-02 15:20 Andrew Rambaut open PDF p.475
   As @Kristian Andersen said - this virus is weird
4. 2021-02-02 15:23 Robert F. Garry open PDF p.475
   Fascinating - I dunno, but short copy-choice error events - 3, 6, 9, 12 bases at a time?
5. 2021-02-02 16:00 Robert F. Garry open PDF p.475
   Only in New Orleans: https://www.bing.com/videos/search?q=3+6+9+the+monkey+drank+wine&view=detail&a mp;mid=36[...]4N1480D022419AA6B84BBD86%26form%3dCONBDF%26conlogo%3dCT3210127
6. 2021-02-02 16:05 Robert F. Garry open PDF p.475
   You may want to watch the version from the Rebelles too...
7. 2021-02-02 16:06 Robert F. Garry open PDF p.475
   I think Frenchie and LuLu might have a little thing going...