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Slack / Private Message Drop, p.443 [SLACK_000657] · slack_pm:msg:04585

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2021-01-23 17:15 Kristian G. Andersen open

Yeah. Very interesting to see how several of these are shared with BRA/RSA variants though - I find that a little confusing
2021-01-23 17:16 Kristian G. Andersen open

I thought the mutations observed in P.1 / B.1.351 were likely fixed in a single individual and then took off in the population. But seeing them pop up here suggest to me that that likely wasn't the case. Maybe immune selection in_the population_, not _intrahost_, actually fixed them in the first place.
2021-01-23 17:17 Kristian G. Andersen open

I think the UK lineage is likely a weird example of a chronic infection that took off, while the BRA/RSA lineages are just a result of selection on the population.
2021-01-23 17:17 Andrew Rambaut open

The plastic ones could have just been hitchhiking in the generating individual
2021-01-23 17:17 Kristian G. Andersen

True
2021-01-23 17:19 Andrew Rambaut open

Trevor has been going around saying the RSA lineage arose in sequence based on some genomes with only some of the mutations but they are not old sequences and I have heard that Tulio uses some weird homebrew bioinformatics that may call for reference occasionally.
2021-01-23 17:20 Kristian G. Andersen open

Eh?
2021-01-23 17:20 Andrew Rambaut open

Exactly
2021-01-23 17:21 Kristian G. Andersen open

That's weird. I mean, P.1. has many overlapping mutations so surely those at least must be right?