Chat message

Slack / Private Message Drop, p.429 [SLACK_000643] · slack_pm:msg:04437

Recipients on this medium are inferred from channel membership, not per-message addressing.

Blue: L452R, Black Y453, Orange H34 ACE2

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-20 07:39 Kristian G. Andersen open

On the Rambaut scale - how alarming do these look to you? It's a little unclear here in San Diego, but I _do_ thinkwe might see it expanding rather rapidly - and in different lineages.
2021-01-20 07:40 Andrew Rambaut open

@Andrew Rambaut They are fairly new but I don't know how fast they are growing. Will look again later today
2021-01-20 08:02 Robert F. Garry open

There is a ton of mischief changing L452R could do. Likely a neutralizing epitope of course. The positive charge onR likely changes the interactions with several other chains. This could improve the interaction between Y453 andH34 on ACE2.
2021-01-20 08:14 Robert F. Garry open

shared file(s): image.png
2021-01-20 08:17 Robert F. Garry

Blue: L452R, Black Y453, Orange H34 ACE2
2021-01-20 08:23 Robert F. Garry open

@Eddie Holmes not sure if Tommy got the link. Not sure (tech?) but I think anyone with this link can log on. https://docs.google.com/document/d/1UMQokOz_gDqE0s9keyI7ES8bC7-55EOFuA4UiznEP08/edit
2021-01-20 08:25 Robert F. Garry open

Anyway I'm pretty much done with the revised text . Everyone under water of course and SUPER busy, but when I get the thumbs up from the channel I'll go ahead and post... Check the last p[aragraph of the discussion for the major change and incorporation of the Tommy data.