Chat message

Slack / Private Message Drop, p.429 [SLACK_000643] · slack_pm:msg:04433

Date: 2021-01-20 07:39
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

On the Rambaut scale - how alarming do these look to you? It's a little unclear here in San Diego, but I _do_ thinkwe might see it expanding rather rapidly - and in different lineages.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-20 06:41 Kristian G. Andersen open

Fuck yeah - top of the world!
2021-01-20 06:43 Kristian G. Andersen open

@Kristian Andersen The false equivalence gets to me every time - so frustrating! I turn all these interviews down, but his questions were different, kinda interesting, and looked honest. You learn every day....
2021-01-20 07:11 Robert F. Garry open

Figure revised to include Tommy's observation - !channel please check details, author order, revisions (almost done with those) etc. [shared file(s): image.png]
2021-01-20 07:39 Kristian G. Andersen

On the Rambaut scale - how alarming do these look to you? It's a little unclear here in San Diego, but I _do_ thinkwe might see it expanding rather rapidly - and in different lineages.
2021-01-20 07:40 Andrew Rambaut open

@Andrew Rambaut They are fairly new but I don't know how fast they are growing. Will look again later today
2021-01-20 08:02 Robert F. Garry open

There is a ton of mischief changing L452R could do. Likely a neutralizing epitope of course. The positive charge onR likely changes the interactions with several other chains. This could improve the interaction between Y453 andH34 on ACE2.
2021-01-20 08:14 Robert F. Garry open

shared file(s): image.png
2021-01-20 08:17 Robert F. Garry open

Blue: L452R, Black Y453, Orange H34 ACE2

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