Slack / Private Message Drop — page 429

[2021-01-20 04:42:44] [Robert Garry] PO2 - Let's go for back to back titles! [2021-01-20 04:52:34] [Robert Garry] [thread - ID: 2021-01-19 22:57:31] @Kristian Andersen Problem is these all set up a false equivalency - it's either natural or lab created/lab escape. Also a mile wide and fraction of an inch deep. Once you delve into any aspect (RaTG13, RnYN02 are fake, FCS in CoVs are rare, SC2 few Ns muts= adapted to humans, etc) you find that these are not two equal things. [2021-01-20 06:41:01] [Kristian Andersen] [thread - ID: 2021-01-20 06:41:01] Fuck yeah - top of the world! [2021-01-20 06:43:30] [Kristian Andersen] [thread - ID: 2021-01-19 22:57:31] @Kristian Andersen The false equivalence gets to me every time - so frustrating! I turn all these interviews down, but his questions were different, kinda interesting, and looked honest. You learn every day.... [2021-01-20 07:11:25] [Robert Garry] Figure revised to include Tommy's observation - !channel please check details, author order, revisions (almost done with those) etc. [shared file(s): image.png] [2021-01-20 07:39:38] [Kristian Andersen] [thread - ID: 2021-01-19 23:17:55] On the Rambaut scale - how alarming do these look to you? It's a little unclear here in San Diego, but I _do_ think we might see it expanding rather rapidly - and in different lineages. [2021-01-20 07:40:54] [Andrew Rambaut] [thread - ID: 2021-01-19 23:17:55] @Andrew Rambaut They are fairly new but I don't know how fast they are growing. Will look again later today [2021-01-20 08:02:29] [Robert Garry] There is a ton of mischief changing L452R could do. Likely a neutralizing epitope of course. The positive charge on R likely changes the interactions with several other chains. This could improve the interaction between Y453 and H34 on ACE2. [2021-01-20 08:14:25] [Robert Garry] shared file(s): image.png [2021-01-20 08:17:02] [Robert Garry] Blue: L452R, Black Y453, Orange H34 ACE2 [2021-01-20 08:23:12] [Robert Garry]