A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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Figure revised to include Tommy's observation - !channel please check details, author order, revisions (almost done with those) etc. [shared file(s): image.png]
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On the Rambaut scale - how alarming do these look to you? It's a little unclear here in San Diego, but I _do_ thinkwe might see it expanding rather rapidly - and in different lineages.
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@Andrew Rambaut They are fairly new but I don't know how fast they are growing. Will look again later today
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There is a ton of mischief changing L452R could do. Likely a neutralizing epitope of course. The positive charge onR likely changes the interactions with several other chains. This could improve the interaction between Y453 andH34 on ACE2.
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2021-01-20 08:14
Robert F. Garry
shared file(s): image.png
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Blue: L452R, Black Y453, Orange H34 ACE2
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@Eddie Holmes not sure if Tommy got the link. Not sure (tech?) but I think anyone with this link can log on. https://docs.google.com/document/d/1UMQokOz_gDqE0s9keyI7ES8bC7-55EOFuA4UiznEP08/edit
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Anyway I'm pretty much done with the revised text . Everyone under water of course and SUPER busy, but when I get the thumbs up from the channel I'll go ahead and post... Check the last p[aragraph of the discussion for the major change and incorporation of the Tommy data.