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Slack / Private Message Drop, p.403 [SLACK_000617] · slack_pm:msg:04157

Page text: p.403 · original PDF

Date
2021-01-15 11:13
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry

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Yeah just looking at the structure L452R could definitely affect ACE2 binding.

In context

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  1. 2021-01-15 11:12 Andrew Rambaut open
    A few from lineage A with N501Y too: Denmark/DCGC-22492/2020,2020-12-14,A,synSNP:A361G|orf1ab:P286L|synSNP:C2509T|synSNP:C8782T|orf1a b:D2980G|orf1ab:N3651S|synSNP:A11326G|synSNP:C16293T|orf1ab:P5401L|synSNP:A18366G|synSNP:A20262 G|S:L18F|synSNP:G22468T|S:L452R|S:*N501Y*|S:A653V|S:H655Y|S:D796Y|S:G1219V|ORF3a:V50A|synSNP:C2 7247T|ORF8:L84S|N:S202N|synSNP:T29344A|N:D358N England/PHEC-150B87/2020,2020-12-23,A,synSNP:A361G|orf1ab:P286L|synSNP:C2509T|synSNP:C8782T|orf1a b:D2980G|orf1ab:N3651S|orf1ab:T4265I|orf1ab:Q4392H|synSNP:C16293T|orf1ab:P5401L|synSNP:A18366G|orf1a b:L6082F|orf1ab:A6544V|synSNP:A20262G|S:L18F|synSNP:C21658T|synSNP:G22468T|S:L452R|S:*N501Y*|S:A6 53V|S:H655Y|S:D796Y|S:G1219V|ORF3a:V50A|synSNP:A26154G|synSNP:C27247T|ORF8:L84S|N:S202N England/PHEC-150B96/2020,2020-12-23,A,synSNP:A361G|orf1ab:P286L|synSNP:C2509T|synSNP:C8782T|orf1a b:D2980G|orf1ab:N3651S|orf1ab:Q4392H|synSNP:C16293T|orf1ab:P5401L|orf1ab:K5542R|synSNP:A18366G|orf1 ab:L6082F|orf1ab:A6544V|synSNP:A20262G|S:L18F|synSNP:C21658T|synSNP:G22468T|S:L452R|S:*N501Y*|S:A 653V|S:H655Y|S:D796Y|S:G1219V|ORF3a:V50A|synSNP:A26154G|synSNP:C27247T|ORF8:L84S|N:S202N
  2. 2021-01-15 11:12 Andrew Rambaut open
    Danish one seems related too
  3. 2021-01-15 11:13 Andrew Rambaut open
    One in combo with E484K: England/MILK-D74161/2020,2020-12-26,B.1.1.10,orf1ab:L446F|synSNP:C3037T|orf1ab:M1378I|synSNP:C4543T|s ynSNP:G8179T|orf1ab:P2739L|orf1ab:Y3063S|orf1ab:P3767L|synSNP:C12406T|orf1ab:P4715L|synSNP:C14805T| orf1ab:T5131I|synSNP:C19170T|synSNP:C19269T|synSNP:G19509A|synSNP:C21811T|S:L452R|S:*E484K*|S:D6 14G|S:Y1155F|S:V1228L|synSNP:A26927G|synSNP:G28079T|N:R203K|N:G204R
  4. 2021-01-15 11:13 Kristian G. Andersen open
    Hmmm. Also L18F
  5. 2021-01-15 11:13 Robert F. Garry
    Yeah just looking at the structure L452R could definitely affect ACE2 binding.
  6. 2021-01-15 11:15 Kristian G. Andersen open
    All are recent too. I'll put that on the list of "ones to watch". I don't want to do this every time a g'damn mutation comes up! We also need somebody to gather all the informationwe have on the various SNPs - binding, Ab escape, structures, etc. - so we can have a simple SNP table... I'll put that on the list.
  7. 2021-01-15 11:18 Kristian G. Andersen open
    shared file(s): L452R variant
  8. 2021-01-15 11:19 Kristian G. Andersen open
    Very fitting. [shared file(s): Screen Shot 2021-01-15 at 11.19.03.png]
  9. 2021-01-15 11:49 Robert F. Garry open
    just tell me when i can update my christmas card

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