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Slack / Private Message Drop, p.402 [SLACK_000616] · slack_pm:msg:04153

Date: 2021-01-15 11:12
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut

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2021-01-15 10:56 Kristian G. Andersen open

What the hell is going on with this binding affinity thingamajig. https://arxiv.org/pdf/2005.14669.pdf
2021-01-15 11:10 Andrew Rambaut open

86 with L452R in England.
2021-01-15 11:11 Kristian G. Andersen open

Recent and on B.1.1.7 background?
2021-01-15 11:11 Kristian G. Andersen open

(and I said LA - it's actually Northern California)
2021-01-15 11:12 Andrew Rambaut

A few from lineage A with N501Y too: Denmark/DCGC-22492/2020,2020-12-14,A,synSNP:A361G|orf1ab:P286L|synSNP:C2509T|synSNP:C8782T|orf1a b:D2980G|orf1ab:N3651S|synSNP:A11326G|synSNP:C16293T|orf1ab:P5401L|synSNP:A18366G|synSNP:A20262 G|S:L18F|synSNP:G22468T|S:L452R|S:*N501Y*|S:A653V|S:H655Y|S:D796Y|S:G1219V|ORF3a:V50A|synSNP:C2 7247T|ORF8:L84S|N:S202N|synSNP:T29344A|N:D358N England/PHEC-150B87/2020,2020-12-23,A,synSNP:A361G|orf1ab:P286L|synSNP:C2509T|synSNP:C8782T|orf1a b:D2980G|orf1ab:N3651S|orf1ab:T4265I|orf1ab:Q4392H|synSNP:C16293T|orf1ab:P5401L|synSNP:A18366G|orf1a b:L6082F|orf1ab:A6544V|synSNP:A20262G|S:L18F|synSNP:C21658T|synSNP:G22468T|S:L452R|S:*N501Y*|S:A6 53V|S:H655Y|S:D796Y|S:G1219V|ORF3a:V50A|synSNP:A26154G|synSNP:C27247T|ORF8:L84S|N:S202N England/PHEC-150B96/2020,2020-12-23,A,synSNP:A361G|orf1ab:P286L|synSNP:C2509T|synSNP:C8782T|orf1a b:D2980G|orf1ab:N3651S|orf1ab:Q4392H|synSNP:C16293T|orf1ab:P5401L|orf1ab:K5542R|synSNP:A18366G|orf1 ab:L6082F|orf1ab:A6544V|synSNP:A20262G|S:L18F|synSNP:C21658T|synSNP:G22468T|S:L452R|S:*N501Y*|S:A 653V|S:H655Y|S:D796Y|S:G1219V|ORF3a:V50A|synSNP:A26154G|synSNP:C27247T|ORF8:L84S|N:S202N
2021-01-15 11:12 Andrew Rambaut open

Danish one seems related too
2021-01-15 11:13 Andrew Rambaut open

One in combo with E484K: England/MILK-D74161/2020,2020-12-26,B.1.1.10,orf1ab:L446F|synSNP:C3037T|orf1ab:M1378I|synSNP:C4543T|s ynSNP:G8179T|orf1ab:P2739L|orf1ab:Y3063S|orf1ab:P3767L|synSNP:C12406T|orf1ab:P4715L|synSNP:C14805T| orf1ab:T5131I|synSNP:C19170T|synSNP:C19269T|synSNP:G19509A|synSNP:C21811T|S:L452R|S:*E484K*|S:D6 14G|S:Y1155F|S:V1228L|synSNP:A26927G|synSNP:G28079T|N:R203K|N:G204R
2021-01-15 11:13 Kristian G. Andersen open

Hmmm. Also L18F
2021-01-15 11:13 Robert F. Garry open

Yeah just looking at the structure L452R could definitely affect ACE2 binding.

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