Slack / Private Message Drop — page 403

[2021-01-15 11:12:29] [Andrew Rambaut] Danish one seems related too [2021-01-15 11:13:15] [Andrew Rambaut] One in combo with E484K: England/MILK-D74161/2020,2020-12-26,B.1.1.10,orf1ab:L446F|synSNP:C3037T|orf1ab:M1378I|synSNP:C4543T|s ynSNP:G8179T|orf1ab:P2739L|orf1ab:Y3063S|orf1ab:P3767L|synSNP:C12406T|orf1ab:P4715L|synSNP:C14805T| orf1ab:T5131I|synSNP:C19170T|synSNP:C19269T|synSNP:G19509A|synSNP:C21811T|S:L452R|S:*E484K*|S:D6 14G|S:Y1155F|S:V1228L|synSNP:A26927G|synSNP:G28079T|N:R203K|N:G204R [2021-01-15 11:13:27] [Kristian Andersen] Hmmm. Also L18F [2021-01-15 11:13:41] [Robert Garry] Yeah just looking at the structure L452R could definitely affect ACE2 binding. [2021-01-15 11:15:51] [Kristian Andersen] [thread - ID: 2021-01-15 11:15:51] All are recent too. I'll put that on the list of "ones to watch". I don't want to do this every time a g'damn mutation comes up! We also need somebody to gather all the information we have on the various SNPs - binding, Ab escape, structures, etc. - so we can have a simple SNP table... I'll put that on the list. [2021-01-15 11:18:35] [Kristian Andersen] shared file(s): L452R variant [2021-01-15 11:19:33] [Kristian Andersen] Very fitting. [shared file(s): Screen Shot 2021-01-15 at 11.19.03.png] [2021-01-15 11:49:02] [Robert Garry] just tell me when i can update my christmas card [2021-01-15 11:49:24] [Robert Garry] shared file(s): image.png [2021-01-15 11:50:46] [Kristian Andersen] Yeah, please keep that confidential for now - the zoo is freaking out... That genome is identical to a zookeeper, so no change of the virus going to the gorilla. We're getting additional samples. [2021-01-15 12:23:10] [Robert Garry] Will do - test some monkeys too. Maybe the tamarins. They are my favorites. [2021-01-15 12:33:45] [Kristian Andersen]