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Slack / Private Message Drop, p.403 [SLACK_000617] · slack_pm:msg:04159

Page text: p.403 · original PDF

Date
2021-01-15 11:18
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

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shared file(s): L452R variant

In context

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  1. 2021-01-15 11:13 Andrew Rambaut open
    One in combo with E484K: England/MILK-D74161/2020,2020-12-26,B.1.1.10,orf1ab:L446F|synSNP:C3037T|orf1ab:M1378I|synSNP:C4543T|s ynSNP:G8179T|orf1ab:P2739L|orf1ab:Y3063S|orf1ab:P3767L|synSNP:C12406T|orf1ab:P4715L|synSNP:C14805T| orf1ab:T5131I|synSNP:C19170T|synSNP:C19269T|synSNP:G19509A|synSNP:C21811T|S:L452R|S:*E484K*|S:D6 14G|S:Y1155F|S:V1228L|synSNP:A26927G|synSNP:G28079T|N:R203K|N:G204R
  2. 2021-01-15 11:13 Kristian G. Andersen open
    Hmmm. Also L18F
  3. 2021-01-15 11:13 Robert F. Garry open
    Yeah just looking at the structure L452R could definitely affect ACE2 binding.
  4. 2021-01-15 11:15 Kristian G. Andersen open
    All are recent too. I'll put that on the list of "ones to watch". I don't want to do this every time a g'damn mutation comes up! We also need somebody to gather all the informationwe have on the various SNPs - binding, Ab escape, structures, etc. - so we can have a simple SNP table... I'll put that on the list.
  5. 2021-01-15 11:18 Kristian G. Andersen
    shared file(s): L452R variant
  6. 2021-01-15 11:19 Kristian G. Andersen open
    Very fitting. [shared file(s): Screen Shot 2021-01-15 at 11.19.03.png]
  7. 2021-01-15 11:49 Robert F. Garry open
    just tell me when i can update my christmas card
  8. 2021-01-15 11:49 Robert F. Garry open
    shared file(s): image.png
  9. 2021-01-15 11:50 Kristian G. Andersen open
    Yeah, please keep that confidential for now - the zoo is freaking out... That genome is identical to a zookeeper, sono change of the virus going to the gorilla. We're getting additional samples.

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