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Slack / Private Message Drop, p.384 [SLACK_000598] · slack_pm:msg:03996

Page text: p.384 · original PDF

Date
2021-01-11 15:35
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

(oh - wait, maybe that was Australia... Somewhere South :wink: )

In context

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  1. 2021-01-11 15:33 Andrew Rambaut open
    Although... there is a Finnish import of the RSA variant that has 681H.
  2. 2021-01-11 15:34 Andrew Rambaut open
    (convergence to the same set of mutations)
  3. 2021-01-11 15:34 Kristian G. Andersen open
    Didn't they mention a couple of months ago that they had a really fast moving lineage that didn't lead to symptoms? I'm wondering if any of that might actually be true - not really "fast" moving, but expanding rapidly and if in a lot ofpeople with previously immunity, maybe leading to less symptoms. That wouldn't be too bad.
  4. 2021-01-11 15:34 Kristian G. Andersen open
    "They" being RSA
  5. 2021-01-11 15:35 Kristian G. Andersen
    (oh - wait, maybe that was Australia... Somewhere South :wink: )
  6. 2021-01-11 15:41 Kristian G. Andersen open
    So just to conclude to see if I got this right: • One lineage rapidly expanding because it's inherently more transmissible - B.1.1.7. • Several other independent lineages - carrying mutations at 417 and 484 - expanding rapidly in areas of high standing immunity, probably due to escape. Possibly, Nelly is innocent - at least partially and she probably isn't alone responsible for the expansion of both theUK and RSA lineages.
  7. 2021-01-11 15:42 Kristian G. Andersen open
    B.1.1.7 might also have an 'immunity' phenotype in addition to the transmission phenotype. We'll know soon enough.
  8. 2021-01-11 15:42 Andrew Rambaut open
    And Nelly on its own (in Wales) is not doing that much
  9. 2021-01-11 15:44 Kristian G. Andersen open
    Yup. We have seen Nelly a couple of times in the US too and never associated with increased transmission (although all of that might just be down to chance). It's very plausible that when Nelly is hanging with her friends she might be naughty, but not when she's alone...

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