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Slack / Private Message Drop, p.384 [SLACK_000598] · slack_pm:msg:03995

Page text: p.384 · original PDF

Date
2021-01-11 15:34
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

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"They" being RSA

In context

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  1. 2021-01-11 15:33 Andrew Rambaut open
    Agree. No comparative rates for RSA. It is just fast growing.
  2. 2021-01-11 15:33 Andrew Rambaut open
    Although... there is a Finnish import of the RSA variant that has 681H.
  3. 2021-01-11 15:34 Andrew Rambaut open
    (convergence to the same set of mutations)
  4. 2021-01-11 15:34 Kristian G. Andersen open
    Didn't they mention a couple of months ago that they had a really fast moving lineage that didn't lead to symptoms? I'm wondering if any of that might actually be true - not really "fast" moving, but expanding rapidly and if in a lot ofpeople with previously immunity, maybe leading to less symptoms. That wouldn't be too bad.
  5. 2021-01-11 15:34 Kristian G. Andersen
    "They" being RSA
  6. 2021-01-11 15:35 Kristian G. Andersen open
    (oh - wait, maybe that was Australia... Somewhere South :wink: )
  7. 2021-01-11 15:41 Kristian G. Andersen open
    So just to conclude to see if I got this right: • One lineage rapidly expanding because it's inherently more transmissible - B.1.1.7. • Several other independent lineages - carrying mutations at 417 and 484 - expanding rapidly in areas of high standing immunity, probably due to escape. Possibly, Nelly is innocent - at least partially and she probably isn't alone responsible for the expansion of both theUK and RSA lineages.
  8. 2021-01-11 15:42 Kristian G. Andersen open
    B.1.1.7 might also have an 'immunity' phenotype in addition to the transmission phenotype. We'll know soon enough.
  9. 2021-01-11 15:42 Andrew Rambaut open
    And Nelly on its own (in Wales) is not doing that much

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