COVID-19 Records

Chat message

Slack / Private Message Drop, p.384 [SLACK_000598] · slack_pm:msg:03994

Page text: p.384 · original PDF

Date
2021-01-11 15:34
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

Didn't they mention a couple of months ago that they had a really fast moving lineage that didn't lead to symptoms? I'm wondering if any of that might actually be true - not really "fast" moving, but expanding rapidly and if in a lot ofpeople with previously immunity, maybe leading to less symptoms. That wouldn't be too bad.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

  1. 2021-01-11 15:32 Kristian G. Andersen open
    (No question about the UK lineage though).
  2. 2021-01-11 15:33 Andrew Rambaut open
    Agree. No comparative rates for RSA. It is just fast growing.
  3. 2021-01-11 15:33 Andrew Rambaut open
    Although... there is a Finnish import of the RSA variant that has 681H.
  4. 2021-01-11 15:34 Andrew Rambaut open
    (convergence to the same set of mutations)
  5. 2021-01-11 15:34 Kristian G. Andersen
    Didn't they mention a couple of months ago that they had a really fast moving lineage that didn't lead to symptoms? I'm wondering if any of that might actually be true - not really "fast" moving, but expanding rapidly and if in a lot ofpeople with previously immunity, maybe leading to less symptoms. That wouldn't be too bad.
  6. 2021-01-11 15:34 Kristian G. Andersen open
    "They" being RSA
  7. 2021-01-11 15:35 Kristian G. Andersen open
    (oh - wait, maybe that was Australia... Somewhere South :wink: )
  8. 2021-01-11 15:41 Kristian G. Andersen open
    So just to conclude to see if I got this right: • One lineage rapidly expanding because it's inherently more transmissible - B.1.1.7. • Several other independent lineages - carrying mutations at 417 and 484 - expanding rapidly in areas of high standing immunity, probably due to escape. Possibly, Nelly is innocent - at least partially and she probably isn't alone responsible for the expansion of both theUK and RSA lineages.
  9. 2021-01-11 15:42 Kristian G. Andersen open
    B.1.1.7 might also have an 'immunity' phenotype in addition to the transmission phenotype. We'll know soon enough.

Full conversation →