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Slack / Private Message Drop, p.382 [SLACK_000596] · slack_pm:msg:03975

Page text: p.382 · original PDF

Date
2021-01-11 15:14
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker
Andrew Rambaut

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Yup. Manaus is not chilly this time of year!

In context

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  1. 2021-01-11 15:12 Kristian G. Andersen open
    Why're we seeing it now and not earlier? More widespread transmission, vaccines being deployed in some places, more standing immunity. But I do feel something's up here - doesn't seem normal to find so many clearly unrelated lineages ending up with a subset of the same mutations. That's just weird.
  2. 2021-01-11 15:13 Andrew Rambaut open
    3 very strange events with similar sets of mutations come up.
  3. 2021-01-11 15:13 Kristian G. Andersen open
    Yeah.
  4. 2021-01-11 15:13 Kristian G. Andersen open
    And in different parts of the world - with different climates, so not e.g., a "cold" adaptation.
  5. 2021-01-11 15:14 Andrew Rambaut
    Yup. Manaus is not chilly this time of year!
  6. 2021-01-11 15:15 Kristian G. Andersen open
    They DID have a fuck ton of infections in the spring though. Same for UK. Same for RSA.
  7. 2021-01-11 15:15 Andrew Rambaut open
    Rare chronic infections could just be a ready source of these mutations in combination (because they can all be selected for in the very large population sizes). When you get the combination it takes off
  8. 2021-01-11 15:16 Andrew Rambaut open
    You just don't get them step by step in normal transmission with bottle necks
  9. 2021-01-11 15:16 Kristian G. Andersen open
    Does Oli/Nuno have any data on reinfections? You mentioned a Virological study yesterday, but not sure if they're looking at that?

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