A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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> It seems like all of these lineages are converging to the same set of mutations And just to this part - it's strongly suggestive of some very pervasive selections pressure that's in common in all these places. Or, alternatively (but I think less likely) something like this: https://www.cell.com/cell/fulltext/S0092-8674(17)30292-1?_returnURL=https%3A%2F%2Fl[...]vier.com%2Fretrieve%2Fpii%2FS0092867417302921%3Fshowall%3Dtrue
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Except that these 3 cases have a shit load of other stuff. Masses of spike mutations (and no synonymous in spike). Orf8 mutations and that nsp6 deletion
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Why're we seeing it now and not earlier? More widespread transmission, vaccines being deployed in some places, more standing immunity. But I do feel something's up here - doesn't seem normal to find so many clearly unrelated lineages ending up with a subset of the same mutations. That's just weird.
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3 very strange events with similar sets of mutations come up.
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2021-01-11 15:13
Kristian G. Andersen
Yeah.
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And in different parts of the world - with different climates, so not e.g., a "cold" adaptation.
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Yup. Manaus is not chilly this time of year!
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They DID have a fuck ton of infections in the spring though. Same for UK. Same for RSA.
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Rare chronic infections could just be a ready source of these mutations in combination (because they can all be selected for in the very large population sizes). When you get the combination it takes off