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Slack / Private Message Drop, p.311 [SLACK_000525] · slack_pm:msg:03267

Date: 2020-12-14 09:51
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

Recipients on this medium are inferred from channel membership, not per-message addressing.

Chronic shedding with immune selection definitely a possibility. N501 is next to a short disordered region in S structures - a clear signal that it's an epitope.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-12-14 09:44 Andrew Rambaut open

Here is the tree... [shared file(s): Kent_N501Y_836.ml_annotated_collapsed_tree.pdf]
2020-12-14 09:44 Kristian G. Andersen open

That's A LOT of mutations - all in one 'jump'?
2020-12-14 09:45 Andrew Rambaut open

There is one intermediate with some of the mutations... hence thought of a chronic shedder
2020-12-14 09:46 Kristian G. Andersen open

Yeah, the spike mutations would suggest chronic - but a lot of mutations outside spike too, which is a little peculiar tome.
2020-12-14 09:51 Robert F. Garry

Chronic shedding with immune selection definitely a possibility. N501 is next to a short disordered region in S structures - a clear signal that it's an epitope.
2020-12-14 09:56 Robert F. Garry open

P681H is also VERY interesting....how common is this?
2020-12-14 10:06 Andrew Rambaut open

There is an ORF8 stop at amino acid 27 and then a number appear after that suggesting it has become non functional.
2020-12-14 10:07 Andrew Rambaut open

@Robert Garry Why do you say that?
2020-12-14 10:09 Andrew Rambaut open

Any thought if it would likely be an immunecompromised patient - could a weak immune response enhance selection for escape? Or do we know of any asymptomatic shedders - which would allow for the transmission if the person was out and about?

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