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Slack / Private Message Drop, p.311 [SLACK_000525] · slack_pm:msg:03269

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There is an ORF8 stop at amino acid 27 and then a number appear after that suggesting it has become non functional.

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2020-12-14 09:45 Andrew Rambaut open

There is one intermediate with some of the mutations... hence thought of a chronic shedder
2020-12-14 09:46 Kristian G. Andersen open

Yeah, the spike mutations would suggest chronic - but a lot of mutations outside spike too, which is a little peculiar tome.
2020-12-14 09:51 Robert F. Garry open

Chronic shedding with immune selection definitely a possibility. N501 is next to a short disordered region in S structures - a clear signal that it's an epitope.
2020-12-14 09:56 Robert F. Garry open

P681H is also VERY interesting....how common is this?
2020-12-14 10:06 Andrew Rambaut

There is an ORF8 stop at amino acid 27 and then a number appear after that suggesting it has become non functional.
2020-12-14 10:07 Andrew Rambaut open

@Robert Garry Why do you say that?
2020-12-14 10:09 Andrew Rambaut open

Any thought if it would likely be an immunecompromised patient - could a weak immune response enhance selection for escape? Or do we know of any asymptomatic shedders - which would allow for the transmission if the person was out and about?
2020-12-14 10:10 Robert F. Garry open

@Robert Garry It's the insertion P in PRRA
2020-12-14 10:11 Robert F. Garry open

@Robert Garry Would be surprising if it didn't affect cleavage...