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Slack / Private Message Drop, p.271 [SLACK_000485] · slack_pm:msg:02817

Page text: p.271 · original PDF

Date: 2020-11-21 08:03
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

I think this is a clear Bob Garry investigation, so no need to add me - but yeah, add us all in acknowledgments :wink:

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-11-21 07:44 Kristian G. Andersen open

The O-linked glycans very likely regulates the FCS site - I don't think it's a mucin-like domain
2020-11-21 07:45 Robert F. Garry open

agree - thou with some of the other Nido spikes there are more than a dozen o-linked sites so mucin-like
2020-11-21 07:48 Kristian G. Andersen open

Here's the reference for the FCS control: https://pubmed.ncbi.nlm.nih.gov/28924042/
2020-11-21 07:57 Robert F. Garry open

Yes - very pertinent which means I need to add this reference and you as a co-author -you already pointed me to the feline CoVs OK? Also OK to add Andrew and Eddie in acknowledgents for helpful discussions and encouragement?Alternatively I think Andrew and Eddie rise to authorship as well - putting all the PO1 authors on minus Ian but plus Prof Bill in A Virological would certainly garner some attention and stir up the Chan, Yan , Relman and Billy krewe.
2020-11-21 08:03 Kristian G. Andersen

I think this is a clear Bob Garry investigation, so no need to add me - but yeah, add us all in acknowledgments :wink:
2020-11-21 08:04 Kristian G. Andersen open

[unless you're scared to face the trolls on your own... :wink: ]
2020-11-21 08:04 Andrew Rambaut open

It would be interesting to test an SC2 with a FCS deletion in ferrets
2020-11-21 08:06 Kristian G. Andersen open

Agreed - Bob and I have discussed these types of experiments previously. Would also be important to do the same in e.g., human lung cells. Don't know if there's an isolate without the FCS though?
2020-11-21 08:12 Robert F. Garry open

The deletion is nonpathogenic in hamsters, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457603/ but yes ferret abetter model. Tulane primate center and other doing monkeys but I don't know latest results.

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