Chat message

Slack / Private Message Drop, p.261 [SLACK_000475] · slack_pm:msg:02723

Date: 2020-11-17 09:16
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen
Topics: Intelligence community assessments

Recipients on this medium are inferred from channel membership, not per-message addressing.

Yup - plausibly this one becomes fixed when big populations get hit. A lot of diversity in the size of the various farms- especially in Denmark (not sure about NL - but I think they have more 'mega' farms).

Extracted statements

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Statement	Grade	Attribution	Stance
A lot of diversity in the size of the various farms- especially in Denmark (not sure about NL - but I think they have more 'mega' farms).	needs context	uncertain explicit hedge	questions

Statement

Grade

Attribution

Stance

A lot of diversity in the size of the various farms- especially in Denmark (not sure about NL - but I think they have more 'mega' farms).

needs context

uncertain explicit hedge

questions

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-11-17 09:13 Andrew Rambaut open

But even with the mink, there are lots of lineages in Marion's trees that don't have Y453F.
2020-11-17 09:13 Kristian G. Andersen open

Yup, I have been hearing you saying this for years - for Ebola too. For SARS we actually got to see some of those mutations because we captured the intermediate host - would be very interesting to see for SARS2 as well, but the mink data is definitely interesting in this regard.
2020-11-17 09:14 Kristian G. Andersen open

Yeah, I'm not quite sure what Y453F is about - might just be marginally beneficial.
2020-11-17 09:15 Andrew Rambaut open

It appears sufficient times in mink to mean it must be selected for but possibly quite weakly. And possibly as a resultof the high density.
2020-11-17 09:16 Kristian G. Andersen

Yup - plausibly this one becomes fixed when big populations get hit. A lot of diversity in the size of the various farms- especially in Denmark (not sure about NL - but I think they have more 'mega' farms).
2020-11-17 09:17 Andrew Rambaut open

Here is a report I wrote for the WHO. To me the most interesting thing is the spike deletion at 69/70 that appears after Y453F and also appears after N469K in humans [shared file(s): Mink-associated_mutations_in_humans.pdf]
2020-11-17 09:18 Andrew Rambaut open

Note also the Utah human - also mink related, also 453F (slightly confidentially).
2020-11-17 09:19 Robert F. Garry open

One thing to be a data parasite (which implies some relationship to the host) and a data thug/thief.
2020-11-17 09:21 Kristian G. Andersen open

Thanks Andrew for sharing - very interested to get your insights into this. Will keep confidential - A LOT of disagreement in DK about how to handle that (most of those discussions driven by people that have no background in any of this...).

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