A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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The other thing that virologists struggle with is that better receptor binding does not equal fitter viruses.
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But even with the mink, there are lots of lineages in Marion's trees that don't have Y453F.
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Yup, I have been hearing you saying this for years - for Ebola too. For SARS we actually got to see some of those mutations because we captured the intermediate host - would be very interesting to see for SARS2 as well, but the mink data is definitely interesting in this regard.
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Yeah, I'm not quite sure what Y453F is about - might just be marginally beneficial.
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2020-11-17 09:15
Andrew Rambaut
It appears sufficient times in mink to mean it must be selected for but possibly quite weakly. And possibly as a resultof the high density.
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Yup - plausibly this one becomes fixed when big populations get hit. A lot of diversity in the size of the various farms- especially in Denmark (not sure about NL - but I think they have more 'mega' farms).
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Here is a report I wrote for the WHO. To me the most interesting thing is the spike deletion at 69/70 that appears after Y453F and also appears after N469K in humans [shared file(s): Mink-associated_mutations_in_humans.pdf]
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Note also the Utah human - also mink related, also 453F (slightly confidentially).
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One thing to be a data parasite (which implies some relationship to the host) and a data thug/thief.